Journal: Journal of Functional Biomaterials
Article Title: Photodynamic Therapy Using IR-783 Liposomes for Advanced Tongue and Breast Cancers in Humans
doi: 10.3390/jfb15120363
Figure Lengend Snippet: ( A ) Result of real-time measurement of HCC827 cell proliferation over 36 h using an incubation monitoring system. HMC liposomes were treated with cells at equivalent concentrations to the respective HMC (10 μM), while controls and liposomes were treated at the same volume as the HMC (100 μL). The white circles represent the control group (5% glucose), while the black circles indicate the liposome group. The white triangles represent the ICG group, and the black triangles indicate the liposome group. The white squares represent the IR-783 group, and the black squares indicate the IR-783 liposome group. The vertical axis represents the number of cells, while the horizontal axis depicts time. Significant discrepancies in cellular proliferation after 36 h were determined exclusively between the control and IR-783 liposome groups. ( B ) Results of MTT assay for measuring the viability of HCC827 cells treated with IR-783 and IR-783 liposomes at 10 μM of IR-783 equivalent after 48 h. The controls and liposomes were treated with 100 μL, which was the same volume as that used for IR-783 and IR-783 liposomes. The cells treated with IR-783 liposomes show significantly lower viability compared with the control cells. The results were analyzed via one-way analysis of variance with Bonferroni’s post-test and are expressed as the mean ± standard deviation ( n = 5, * p < 0.05, ** p < 0.01). ICG: indocyanine green; Lipo: liposomes.
Article Snippet: After 24 h, cells were treated with ICG, ICG liposomes, IR-783, and IR-783 liposomes with 10 μM of the respective HMC equivalents, and cell growth was monitored using an incubation monitoring system (Olympus CM30).
Techniques: Incubation, Liposomes, Control, MTT Assay, Standard Deviation
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